| Title | The Three Genome Problem |
|---|---|
| Contributor | David H. Silver(author) |
| DOI | https://doi.org/10.11647/OBP.0526.49 |
| Landing page | https://www.openbookpublishers.com/books/10.11647/obp.0526/chapters/10.11647/obp.0526.49 |
| License | https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright | David H. Silver |
| Publisher | Open Book Publishers |
| Published on | 2026-04-08 |
| Long abstract | Every human inherits two distinct genomes: nuclear DNA from both parents and mitochondrial DNA almost exclusively from the oocyte. This second genome — 37 genes controlling cellular energy production — mutates 10-100 times faster than nuclear DNA, causing devastating diseases when defective. Traditional IVF cannot prevent mothers from passing faulty mitochondria to children. Enter mitochondrial replacement therapy: scientists transfer nuclear DNA from an affected mother’s egg into a donor egg with healthy mitochondria. From single-base edits to chromosome transfers — many ethical questions arise to be discussed. |
| Print length | 10 pages |
| Language | English (Original) |
| THEMA |
|
| BISAC |
|
| Keywords |
|
| Landing Page | Full text URL | Platform | |||
|---|---|---|---|---|---|
| https://www.openbookpublishers.com/books/10.11647/obp.0526/chapters/10.11647/obp.0526.49 | Landing page | https://books.openbookpublishers.com/10.11647/obp.0526.49.pdf | Full text URL |
David H. Silver is an industrial researcher whose career bridges computer vision, computational biology, and science communication. He studied mathematics, computer science, and biology at the Technion — Israel Institute of Technology as a Rothschild Scholar, and was awarded a Microsoft Research PhD Fellowship for his doctoral work in computational biology at Cambridge, UK. Silver’s peer-reviewed publications span multiple domains: computational biology in Nature and PNAS; computer vision systems in IEEE Transactions on Pattern Analysis and Machine Intelligence; medical AI in Human Reproduction and MIDL; and entertainment analysis in PLoS One. He holds over a dozen patents in depth sensing, medical imaging, and generative AI. His industry positions include Algorithm Engineer at Intel Corporation, ML Researcher at Apple, and CTO/co-founder roles at several technology startups. Silver maintains academic collaborations with researchers worldwide and serves as a peer reviewer for Image and Vision Computing and PNAS.