| Title | Slices of Life |
|---|---|
| Contributor | David H. Silver(author) |
| DOI | https://doi.org/10.11647/OBP.0526.40 |
| Landing page | https://www.openbookpublishers.com/books/10.11647/obp.0526/chapters/10.11647/obp.0526.40 |
| License | https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright | David H. Silver |
| Publisher | Open Book Publishers |
| Published on | 2026-04-08 |
| Long abstract | DNA sequencing has evolved from Sanger’s chain-termination method through the next-generation revolution of 454 pyrosequencing, Ion Torrent, and Illumina platforms to modern nanopore technologies. The computational challenge of genome assembly uses sophisticated algorithms like de Bruijn graphs to reconstruct complete genomes from millions of short fragments, while paired-end chemistry and long-read technologies help resolve repetitive regions that have long frustrated genomic reconstruction efforts. |
| Print length | 10 pages |
| Language | English (Original) |
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| Landing Page | Full text URL | Platform | |||
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| https://www.openbookpublishers.com/books/10.11647/obp.0526/chapters/10.11647/obp.0526.40 | Landing page | https://books.openbookpublishers.com/10.11647/obp.0526.40.pdf | Full text URL |
David H. Silver is an industrial researcher whose career bridges computer vision, computational biology, and science communication. He studied mathematics, computer science, and biology at the Technion — Israel Institute of Technology as a Rothschild Scholar, and was awarded a Microsoft Research PhD Fellowship for his doctoral work in computational biology at Cambridge, UK. Silver’s peer-reviewed publications span multiple domains: computational biology in Nature and PNAS; computer vision systems in IEEE Transactions on Pattern Analysis and Machine Intelligence; medical AI in Human Reproduction and MIDL; and entertainment analysis in PLoS One. He holds over a dozen patents in depth sensing, medical imaging, and generative AI. His industry positions include Algorithm Engineer at Intel Corporation, ML Researcher at Apple, and CTO/co-founder roles at several technology startups. Silver maintains academic collaborations with researchers worldwide and serves as a peer reviewer for Image and Vision Computing and PNAS.